Pharmacokinetics and pharmacodynamics of clozapine. Jann MW(1), Grimsley SR, Gray EC, Chang WH. Author information: (1)Department of Pharmacy Practice, Mercer University, Southern School of Pharmacy, Atlanta, Georgia. Clozapine (CZP) is an atypical antipsychotic agent commonly used in the treatment of schizophrenia. It is metabolized primarily by CYP1A2 enzyme, yielding a pharmacologically active metabolite, norclozapine (NCZP). Significant intra- and interindividual pharmacokinetic (PK) variability for CZP and NCZP has been observed in routine therapeutic. Clozapine tablets can be taken with or without food [see Pharmacokinetics (12.3)]. Maintenance Treatment Generally, patients responding to Clozapine tablets should continue maintenance treatment on their effective dose beyond the acute episode. Clozapine is a tricyclic dibenzodiazepine antipsychotic drug that is commonly used in the treatment of schizophrenia, particularly in patients who are refractory or intolerant to the side effects. Up to now, it is not yet clear whether and how clozapine and its metabolites are metabolized in neuronal cells. The interconversion of clozapine and its metabolites, clozapine-N-oxide and norclozapine, was studied in the hippocampal neuronal in vitro system of HT22 cells. Pharmacokinetics of clozapine and its metabolites in psychiatric patients: plasma protein binding and renal clearance G Schaber , 1 I Stevens , 2 H J Gaertner , 2 K Dietz , 3 and U Breyer-Pfaff 1 1 Department of Toxicology, University of Tübingen, Tübingen, Germany Clozapine, sold under the brand name Clozaril among others, is an atypical antipsychotic medication. It is mainly used for schizophrenia that does not improve following the use of other antipsychotic medications. In. Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration Summary. The introduction of clozapine has given clinicians a unique agent for treating patients with schizophrenia that is refractory to other neuroleptics.