Best Answer: M357 is vicodin (hydrocodone + acetaminophen). It has different effects on different people. For some people, it doesn't cause euphoria at all. For some people it does. Either way, getting high off of it is a really bad idea, because it's a highly addictive opiate. Hi KarmaKit, Yes it is addictive, and yes it can get a person high if it is taken when not needed or abused, especially if snorted or injected. Pill with imprint M357 is White, Elliptical / Oval and has been identified as Acetaminophen and Hydrocodone Bitartrate 500 mg / 5 mg. It is supplied by Mallinckrodt Pharmaceuticals. Seriously, I wouldn't do it. Unless you're really hurting. It can tear your stomach to shreds. Lortab 5's don't have any sort of coating for your stomach. Dont Tell Me About How Bad Drugs Are for You. I'm Not Retarded with my drugs. I know that 1 vic and 1 perc wont kill me. I Just Need to Know If It'll Get Me High. I'm 6'2 , and weigh 185lbs. Thanky. Please Reply As Soon as Possible. I have been on and off of hydrocodone 5's for the past 2 1/2 years. For all of my teenage years, my mom was prescribed (and still is) hydrocodone and it sat openly in a bottle on her desk, I never touched it. No one can accurately say what dose you need to feel relaxed on Alprazolam and what the chance is you'll get disinhibited and act out crazy only to regret it later, so you're better off to find. You gotta get at least 3 pills, then take 2 and crush them up and put the powder in a thin piece of napkin or something ( that's called (parachuting) and then swallow with a fair amount of liquid. Can you get high off of vicodin that has m357 on the back? Best Answer: It's an opiate derivative, so yes, you can get a high from it if you haven't built up an opiate tolerance..