Find patient medical information for Premarin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Premarin withdrawal symptoms may include the return of the menopausal symptoms an individual experienced before taking hormone replacement therapy. The severity of withdrawal symptoms depends on the severity of a woman's menopausal symptoms prior to starting hormone replacement therapy, reports Women to Women. Side effects that may occur when a person stops taking Premarin include night sweats, irritability, hot flashes and vaginal dryness, according to Elizabeth Hanes, a general medicine nurse writing for WebMD. Also, I started using a Premarin cream twice a week after I saw the urogynecologist a week and a half ago. Read More Two weeks ago, I asked my doctor to put me on HRT because of terrible mood swigns and, of course, hot flashes. Along with its needed effects, conjugated estrogens (the active ingredient contained in Premarin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Premarin Vaginal Cream (conjugated estrogens) is a mixture of estrogen hormones, a female sex hormone produced by the ovaries, used to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse. Consult with your doctor or gynecologist about stopping Premarin if you experience any of the uncomfortable side effects know to be associated with the drug. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Stopping hormone therapy risks Taking estrogen or estrogen and progesterone hormones can help alleviate some bothersome symptoms of menopause, like hot flashes, vaginal dryness and trouble sleeping, but the United States Preventive Services Task Force recommends that postmenopausal women avoid the therapy due to an increased risk of heart disease, stroke, dementia and breast cancer. How to use Premarin Cream With Applicator. Read the Patient Information Leaflet if available from your pharmacist before you start using this medication and each time you get a refill.