Important Information. Indomethacin can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. User Reviews for Indomethacin. Also known as: Indocin, Indocin SR, Tivorbex. The following information is NOT intended to endorse drugs or recommend therapy. Indomethacin is used to relieve moderate to severe pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), and ankylosing spondylitis (arthritis that mainly affects the spine). Prednisone is a corticosteroid drug used to treat different conditions such as allergic disorders, immune system diseases, chronic obstructive pulmonary disease, psoriasis, skin problems, ulcerative colitis, spinal cord injuries, eye problems, arthritis, lupus, organ transplantation, and Addison's disease. Indomethacin (Indocin) is a prescription drug used to treat moderate to severe pain, swelling, and stiffness from arthritis. Allergies. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. everything has come back negative. i was put on prednisone and celabrex eight weeks ago, am still on it. helps to take the inflamation down some but i am still in pain and can hardly walk. There are several prednisone packs on the market, but the most common is a six day pack, which usually includes 21 pills. These pills are taken 6 pills the first day, 5 pills the second day, 4 pills the third day, 3 pills the fourth day, 2 pills the fifth day, and 1 pill the sixth day. What Is Medcillary? Medcillary is revolutionizing the field of ancillary medicine as a one-stop-shop for physicians, clinics and hospitals. Medcillary connects practitioners with a complete package of ancillary services–promoting efficiency, compliance and clinical relevance. What should I discuss with my healthcare provider before taking indomethacin (Indocin, Indocin SR, Tivorbex)? Indomethacin can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease.