5. Tips. Take with food and a full glass of water to reduce the risk of prednisone adversely affecting your stomach. Single doses are preferred over split doses; however, larger dosages may be split. Prednisone Converted Into Prednisolone in Liver. While both these drugs essentially are the same, there is a key difference in regards to how they are metabolized. Prednisone is a prescription drug that is used to help decrease inflammation and suppress an overactive immune system. The medication comes in either liquid or tablet form and is taken just once a day or several times a day, depending on the condition being treated. After the development of shock against a background of acute allergy, I was prescribed Prednisone 10 mg pills. I can say with confidence that this drug helped not only to improve my condition, but also literally saved my life because I suffered a sharp decrease in my blood pressure and lost consciousness. Not all people who take prednisone have side-effects. The side-effects are largely related to the dose and the length of time that the medication is taken. While a drink or two might not have any impact on your health while you take prednisone, it’s always best to talk to your doctor first to avoid complications and give you the best outcome. Prednisone dosing may be complicated and not uncommonly start with a higher dose which is gradually reduced over days to weeks. There is a fine line between too much or too little prednisone. Prednisone is a corticosteroid drug used to treat different conditions such as allergic disorders, immune system diseases, chronic obstructive pulmonary disease, psoriasis, skin problems, ulcerative colitis, spinal cord injuries, eye problems, arthritis, lupus, organ transplantation, and Addison's disease. Prednisone comes as a tablet, a solution (liquid), and a concentrated solution to take by mouth. Prednisone is usually taken with food one to four times a day or once every other day. If you're taking certain prescription medications, ashwagandha supplementation may be inappropriate. Concomitant use of ashwagandha and immunosuppressants, such as prednisone, azathioprine, cyclosporine and basiliximab, should be avoided.