Dosage of LEVAQUIN ® Tablets in Adult Patients with Creatinine Clearance ≥ 50 mL/minute. The usual dose of LEVAQUIN ® Tablets is 250 mg, 500 mg, or 750 mg administered orally every 24 hours, as indicated by infection and described in Table 1. Medscape - Infection dosing for Levaquin, Levofloxacin Systemic (levofloxacin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Figure 1. Profile of plasma levofloxacin concentration during and after a hemodialysis (HD) session. Patients used 500 mg of the drug after HD on the first day and 250 mg 4 hours before HD on the third day. Systemic quinolones have been associated with disabling and potentially irreversible serious adverse reactions such as tendinopathy, including tendinitis and tendon rupture requiring surgical repair or resulting in prolonged disability. Neither hemodialysis nor continuous ambulatory peritoneal dialysis (CAPD) is effective in removal of levofloxacin from the body, indicating that supplemental doses of levofloxacin are not required following hemodialysis or CAPD [see Dosage and Administration (2.3)]. A levofloxacin regimen of 250 mg every 48 h, as recommended by the manufacturer for anuric patients receiving conventional hemodialysis, appears to be subtherapeutic in patients receiving CRRT since, based on the present study, that dose will not produce adequate C max or AUC 0–24 values. The usual dose of LEVAQUIN® Injection is 250 mg or 500 mg administered by slow infusion over 60 minutes every 24 hours or 750 mg administered by slow infusion over 90 minutes every 24 hours, as indicated by infection and described in Table 1. Detailed Levofloxacin dosage information for adults and children. Includes dosages for Urinary Tract Infection, Sinusitis, Bronchitis and more; plus renal, liver and dialysis adjustments. Medical uses. Levofloxacin is used to treat infections including: respiratory tract infections, cellulitis, urinary tract infections, prostatitis, anthrax, endocarditis, meningitis, pelvic inflammatory disease, traveler's diarrhea, tuberculosis, and plague and is available by mouth, intravenously, and in eye drop form.