Lasting Health Effects. Chronic use or abuse of sedatives is associated with: 6. Cognitive deficits. Psychomotor impairment. Dependence. Addiction. In a meta-analysis of individuals using benzodazepines on a long-term basis, cognitive impairments were noted upon withdrawal and remained at follow-up. Long term effects of Xanax (alprazolam) use can include: mood swings, loss of appetite, lethargy, difficulty concentrating and many more. close What To Expect. Seeking addiction treatment can feel overwhelming. We know the struggle, which is why we're uniquely qualified to help. Your call is confidential, and there's no pressure to commit to treatment until you're ready. Adderall's side effects including: physical damage to the brain, internal systems, and organs are the results of a long-term abuse of an addictive drug. How long does it take for the effects of Xanax to wear off? One way to find out how long a drug will last in the body is to measure its half-life. How should I take kava? When considering the use of herbal supplements, seek the advice of your doctor. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements. What are the long-term effects of Xanax use on the brain if taken exactly as directed? It seems that my mind feels like it is stuck in the mud, hazy and there is a feeling of a disconnect with the. As the other posted responded, you should not have any concerns being on xanax at a low dose long term other than tolerance and dependance. I have been a low dose of Valium for over 5 years. Buspar is the medication you are looking for.its ideal for long term use, no sedative or withdrawal or cognitive impairment side effects. Takes three weeks to start working, and have to get up to dose of 30 mg./day to be most effective. The effects of long-term benzodiazepine use include drug dependence and neurotoxicity as well as the possibility of adverse effects on cognitive function, physical health, and mental health. Benzodiazepines are generally effective when used therapeutically in the short term, but even then the risk of dependency can be significantly high.