In spite of high prevalence of irritable bowel syndrome (IBS), current treatments have not been satisfied absolutely. The potential role of antidepressant in IBS treatment is increasingly investigated. Until now, a few studies have evaluated the effect of fluoxetine on IBS symptoms, but they had Question. I have been suffering with irritable bowel syndrome for about seven years. My doctor has just started me on fluoxetine to see if this improves the cramping, bloating and diarrhoea attacks. Hey leesenj, Yes, the prozac may well help the IBS brought on by anxiety and stress. You may have some mild side effects when you first start the prozac. Although widely prescribed, the evidence for the use of antidepressants for the treatment of irritable bowel syndrome (IBS) is limited. In this study, we hypothesized that fluoxetine (Prozac), a. Has anyone else taken prozac for ibs.my Dr precribed them, I have been on them for 2 weeks, but they give me headache and make me itch.Has anyone had any success taking these for ibs and how long before feeling benifits?. Taking antidepressants for IBS is getting on to dangerous ground and some have more side effects than it is worth the risk taking. If you are not depressed then it is inadvisable to start taking strong antidepresssants such as Prozac for IBS. Hi. I've suffered from IBS, anxiety and depression on and off for about 10 yers. I've just been prescribed Fluoxetine 20mg a day, and been taking them for 11 days now. Hey gang! Hope everyone is doing okay and is feeling as stable, happy and healthy as possible today I've just started taking the anti-depressant Fluoxetine yesterday to try and control my anxiety (and therefore my ibs) and it's proving a royal pain with my symptoms. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant. Fluoxetine affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. The following overview will answer the question of why antidepressants are sometimes used as a treatment for IBS and educate you as to the types of antidepressants that are commonly prescribed to IBS patients.