Here are some side effects of Clobetasol which are as follows: application site reactions (burning, irritation, itching and redness), Skin thinning. It is a list of possible side-effects which may occur due to the constituting ingredients of Clobetasol. Clobetasol propionate is classed as a very potent topical corticosteroid. Topical corticosteroids are also referred to as topical steroids. Topical steroids are used in addition to moisturisers (emollients) for treating inflammatory skin conditions such as eczema and dermatitis. In controlled clinical trials, the most frequent adverse events reported for clobetasol propionate ointment were burning sensation, irritation, and itching in 0.5% of treated patients. Less frequent adverse reactions were stinging, cracking, erythema, folliculitis, numbness of fingers, skin atrophy, and telangiectasia. SIDE EFFECTS. Cormax Ointment is generally well tolerated when used for two-week treatment periods. The most frequent adverse reactions reported for clobetasol propionate ointment have been local and have included burning sensation, irritation, and itching. In controlled clinical trials, the most frequent adverse reactions reported for clobetasol propionate cream were burning and stinging sensation in 1% of treated patients. Less frequent adverse reactions were itching, skin atrophy, and cracking and fissuring of the skin. Before using Clobetasol, I found that my topical estrogen that I've already been using provided some relief for the burning, but since using Clobetasol has now upset things even worse, Vaseline is the only thing that is now providing some relief. Applies to clobetasol topical: compounding powder, topical cream, topical foam, topical gel, topical kit, topical lotion, topical ointment, topical shampoo, topical solution, topical spray General The most common side effect reported was skin discomfort. Summary. Burning sensation is found among people who take Clobetasol propionate, especially for people who are female, 60+ old , have been taking the drug for 1 month, also take medication Metformin, and have Rashes. Burning sensation is reported only by a few people who take Clobex. We study 973 people who have side effects while taking Clobex from FDA. Among them, 4 have Burning sensation. Find out below who they are, when they have Burning sensation and more. Clobetasol propionate gel, cream and ointment contain the active compound clobetasol propionate, a synthetic corticosteroid, for topical dermatologic use. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.