Prednisone is a synthetic steroid that can be often prescribed to treat all sorts of medical ailments. In fact, you may have also probably used prednisone if you have bad allergies, Crohn’s disease, Addison disease, or colitis! Hi there! If you’ve come here on Dr. Magnusson’s recommendation to learn about prednisone, you’re in the right place. Prednisone is a very powerful anti-inflammatory drug. Answer by Amanda65 (1220) If you stop prednisone too quickly then you can have a rebound effect. The long-term effects of prednisone can often be severe and irreversible, leading to an increased risk of osteoporosis (bone loss), cataracts (clouding of the eyes), and the development of diabetes. I have recently discovered I'm allergic to an antibiotic that was prescribed to me. The doctor then prescribed 40mg of Prednisone for one week, and 20mg the following week, along with Benadryl and Pepcid. For starters, if you are taking a medication that is controlling an ongoing medical problem like high blood pressure, diabetes or high cholesterol, you should never stop it on your own—or your problem will return. Many patients do report that they just plain stopped their meds though. So when is stopping your medication dangerous? Abruptly. There are arguments pro and con regarding taper. Three days of 60 mg a day will not cause harm if you abruptly stop, although a taper is recommended. There are several prednisone packs on the market, but the most common is a six day pack, which usually includes 21 pills. These pills are taken 6 pills the first day, 5 pills the second day, 4 pills the third day, 3 pills the fourth day, 2 pills the fifth day, and 1 pill the sixth day. Prednisone is similar to cortisol, a hormone naturally made by your adrenal glands. If you take prednisone for more than a few weeks, your adrenal glands decrease cortisol production. Can you abruptly stop taking prednisone after taking 25 mg a day for 30 days? Asked 4 Oct 2013 by javierdfm Updated 9 October 2013 Topics prednisone, doctor, tapering.