Some people experience side effects when taking Zoloft, and weight gain is a possible side effect of the drug. To avoid gaining weight on this medicine, you should eat a healthy diet that includes plenty of fruits, vegetables, and whole grains. Sertraline (Zoloft) is a prescription medication indicated for the treatment of major depressive disorder and panic disorder in adults. Learn about side effects, drug interactions, dosages, warnings, and more. 2.1 Dosage in Patients with MDD, OCD, PD, PTSD, and SAD. The recommended initial dosage and maximum ZOLOFT dosage in patients with MDD, OCD, PD, PTSD, and SAD are displayed in Table 1 below. Dosage in Patients with MDD, OCD, PD, PTSD, and SAD. The recommended initial dosage and maximum ZOLOFT dosage in patients with MDD, OCD, PD, PTSD, and SAD are displayed in Table 1 below.