Yes, the pain medication, hydrocodone, and antibiotic, amoxicillin, can safely be taken together. Although, you may want to take them with food if you experience stomach upset (nausea). To be honest, you are not going to experience anything too abnormal if you take hydrocodone and oxycodone together. I really doubt you will experience a noticeable difference than when you take an equal amount of one, either oxycodone or hydrocodone. Hydrocodone may cause life-threatening withdrawal symptoms in a newborn if the mother has taken this medicine during pregnancy. Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing. Oxycodone and hydrocodone are prescription pain medications. Both can treat short-term pain caused by an injury or surgery. They may also be used to treat pain that is chronic, or long-term. Most hydrocodone is formulated in combination with a second analgesic, such as paracetamol (acetaminophen) or ibuprofen. Examples of hydrocodone combinations include Norco, Vicodin, Lortab, Vicoprofen and Riboxen. I took a Hydrocodone pill last night for pain. It helped some. Now I am hurting again but do not want to take one, but would like at least an hour of no pain. Hydrocodone is usually taken once every 12 hours. However, one needs to follow the directions given in the prescription label as per the doctor's advice. However, one needs to follow the directions given in the prescription label as per the doctor's advice. The most common side effects of hydrocodone are blurred vision, constipation, difficulty breathing, dizziness, drowsiness, flushing, lightheadedness, mental or mood changes, nausea, and vomiting. Hydrocodone comes as an extended-release (long-acting) capsule and an extended-release (long-acting) tablet to take by mouth. The extended-release capsule is usually taken once every 12 hours.