I experienced chest pain,abdominal pain, loss of appetite, migraines,eye pain, loss of eyesight, throat irritation and chronic sinusitis. I felt terrible and suggest that before taking this drug you read all side effect first and pay attention to all signs. I never want to take this drug again. Hopefully I will feel better soon. “ Side Effects: Abdominal pain, tightness of chest, back pain, ankle and wrist pain. nausea. I am alergic to statin based drugs. I have been hospitalized from taking them. My physician pres. I am alergic to statin based drugs. Zetia May Cause Muscle Problems Terry Graedon The People's Pharmacy August 3, 2007 Cramps (hands, legs) 98 Comments With so many drugs now available to lower cholesterol, people naturally would like to know about the benefits and risks of each. Summary. Chest pain is found among people who take Zetia, especially for people who are female, 60+ old , have been taking the drug for 1 month, also take medication Lipitor, and have High blood pressure. Learn about the potential side effects of Zetia (ezetimibe). Includes common and rare side effects information for consumers and healthcare professionals. I recommend you continue to work with your cardiologist to figure out how to get over your symptoms. Living w/ chest pain/pressure and stents is not an easy road, and I hope you get over the hump soon. Chest discomfort is found among people who take Zetia, especially for people who are female, 60+ old , have been taking the drug for 1 month, also take medication Lipitor, and have High blood pressure. View detailed reports from patients taking zetia who experienced chest pain. Reports are from official medical reports as well as online extractions from user reviews and forum discussions. If you are taking Zetia and muscle pain, tenderness, or weakness occurs (especially if it is accompanied by a fever or feeling of illness), you should contact your healthcare provider immediately. Ever since I started taking Zetia and Fenofibrate together as recommended by my DR, I have put on pounds, am more bloated around the belly,a nd have persistent chest pains.