Cause More Pain By Taking OxyContin, Percocet, Lortab & Vicodin It is estimated that a significant percentage of people taking opioid painkillers for chronic pain are actually causing more pain by taking the drugs — an effect called Opioid Induced Hyperalgesia (OIH). So OxyContin lasts for 12 hrs where as Vicodin lasts 4-6hrs. It is also VERY important to spell OxyContin correctly because it can easily be mixed up. There are several other drugs that contain oxycodone including Percocet (oxycodone/acetaminophen), Percodan (oxycodone/aspirin), and OxyIR (oxycodone). Oxycodone is a strong opioid narcotic pain reliever (analgesic), and Vicodin is a combination of two drugs, hydrocodone (a strong narcotic pain reliever) and acetaminophen (Tylenol). Taking oxycodone during pregnancy may cause life-threatening withdrawal symptoms in the newborn. Fatal side effects can occur if you use OxyContin with alcohol, or with other drugs that cause drowsiness or slow your breathing. Because Vicodin carries a high risk of physical and emotional dependence, anyone taking the drug should be aware of the warning signs of addiction, including: Feeling ill when you run out of Vicodin (including muscle pain, joint pain, night sweats, anxiety, jitters, and insomnia) Hey gltwyman, Yes you can take vicodin and oxycontin (oxycodone) in the same day as long as you space them out. If you are taking the oxycontin every 4 to 6 hours, take the vicodin for break through pain in between like at 2 to 3 hours. Percs will show + for opiates, as will vicodin, oxycontin, darvocet, roxicet, etc etc. you get my drift. There is no way they tell whether you're taking percs or vikes- what they CAN do, if they have the time/and or resources is test for the amount of opiates in your system- but they seldom do that. Vicodin and Percocet are powerful drugs, so you should be aware of the risks involved with taking them. Dependence and withdrawal Even if you take them exactly as prescribed, Vicodin or Percocet. Research also shows people who start taking a long-acting opioid or tramadol (Ultram) are more likely to stay on opioids than those given hydrocodone (Vicodin) or oxycodone (Oxycontin). Warning signs If you chose to have a drink, and you also are taking Oxycontin, Vicodin or Percocet, don't drive. Please. There is no way to know for sure you can safely operate a vehicle. Your life and the lives of others are at risk.