Compare Vistaril vs. Zofran, which is better for uses like: Nausea and Vomiting. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Vistaril and Zofran evenly with 3.4/5. - Page 3 Nous voudrions effectuer une description ici mais le site que vous consultez ne nous en laisse pas la possibilité. Zofran (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting. Zofran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment. I took some atarax 75mg for the itching because it was getting a little worse, some amitriptyline 25mg for anxiety, that way the high will last a bit longer and some zofran 8mg because I didn’t want to puke while my parents were around. Best Answer: Vistaril and Zofran can be safely taken together, though the Zofran may increase the drowsiness effect of Vistaril. Vistaril is an antihistamine that can be used to help with nausea and is commonly prescribed as a sleep aid. Compare Vistaril vs. Zofran, which is better for uses like: Nausea and Vomiting. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Vistaril and Zofran evenly with 3.4/5. Ondansetron (Zofran) is a moderately priced drug used to treat nausea and vomiting caused by chemotherapy. It is also used to prevent or treat nausea and vomiting after surgery. Summary. Drug interactions are reported among people who take Zofran and Hydroxyzine together. This study is created by eHealthMe based on reports of 776 people who take Zofran and Hydroxyzine from FDA, and is updated regularly. We studied 2 people who take Vistaril and Zofran odt from FDA. Drug interactions are found. See what they are, when they happen and for whom.