Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Drug Information on Skelaxin (metaxalone) includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid. 4) Metaxalone (Skelaxin) Taken as 800 mg tablets three to four times a day, metaxalone has the fewest reported side effects and lowest sedation potential of the muscle relaxants based on clinical studies. The most common reason for missing work or limited activity for individuals these days is because of back pain. The first thing that doctors recommend in treating back pain is to prescribe medications which often include nonsteroidal anti-inflammatory drugs. Return To Main Guidelines Fibromyalgia Guide. Prescription Medications. Fibromyalgia symptoms are chronic, which means they are persistent long-term. Pfizer for Professionals 1-800-505-4426. The information provided in this site is intended only for health care professionals in the United States. Pain medications are drugs used to relieve discomfort associated with disease, injury, or surgery. Because the pain process is complex, there are many types of pain drugs that provide relief by acting through a variety of physiological mechanisms. Skelaxin (metaxalone) is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) in the brain. Skelaxin is used together with rest and physical therapy to treat skeletal muscle conditions such as pain or injury. METAXALONE is a muscle relaxer. It is used to treat pain and stiffness in muscles caused by strains, sprains, or other injury. The lowest GoodRx price for the most common version of generic Skelaxin is around $36.57, 74% off the average retail price of $143.89. Cialis over the counter at Walmart - Order Cialis Generic (Tadalafil) pills online without prescription: discount for products, the lowest prices, very high quality, descreet packaging and fast worldwide shipping. Order online now!.