Applies to ranitidine: compounding powder, injectable solution, intravenous solution, oral capsule, oral granule effervescent, oral syrup, oral tablet, oral tablet effervescent General The most commonly reported side effect for IM administration was injection site pain, and the most commonly reported side effects with IV administration were localized pain and burning. Common Questions and Answers about Ranitidine side effects long term zantac The weird side effects continued and new side effects emerged such as white hair. hair falling out, weight loss. muscle soreness. stomach pain, and runny nose. In the short term they can cause a number of dose-dependent side effects including commonly headache and diarhea. Longer term use carries other consequences (please see my earlier answer on this topic in healthtap)--like bone thinning, low magnesium, c.Difficile. Are heartburn medications safe for long — term use? Are some more effective and safer than others, or does it depend on the patient? Are some more effective and safer than others, or does it. Avoid long-term use of antacids Antacids — sold in pharmacies without prescription under names such as Rennie and Gaviscon — will neutralise the effects of stomach acid. Long-term use of Zantac may increase the likelihood of developing pneumonia. A study reported in the September 2011 issue of World Journal of Methodology analyzed the combined results of several previously published studies. Hi Linda: There is an ongoing debate about the risks associated with long-term use of Proton Pump Inhibitors ( PPIs ). Some claim that, since they have been in use in Europe for a longer period than America, and that there doesn't appear to be strong evidence of adverse effects from long-term use in Europe, you should be OK. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Williams on long term use of ranitidine side effects: In calcium absorption is one, leading to increase risk of osteoporosis. Ranitidine is used for long-term or short-term treatment. It comes with serious risks if you don’t take it as prescribed. It comes with serious risks if you don’t take it as prescribed.