Cymbalta can increase the effects of alcohol, such as increasing the symptoms of depression or affecting motor skills. Therefore, some healthcare providers recommend that people should not combine Cymbalta and alcohol. Side effects of Cymbalta include dry mouth, drowsiness, fatigue, nausea and constipation. Seek medical help immediately if you experience severe nausea, dark urine, yellow skin, severe agitation, hallucination, fever, fast heat rate, tremors, unusual bleeding, difficulty urinating, severe headache or significant changes in mood or mental function while taking it. Duloxetine (Cymbalta) is a moderately priced drug used to treat depression, anxiety, fibromyalgia, and nerve pain associated with diabetes (diabetic peripheral neuropathy). Drinking alcohol may increase some serious side effects of Cymbalta. Cymbalta may cause high blood pressure. It can also cause dizziness or lightheadedness, especially when you get up too quickly. Drinking in quantity as you are ultimately makes the depression worse. Anxiety is a natural response to cutting back on the alcohol, but will gt better with continued reduction of alcohol consumption. Along with its needed effects, duloxetine (the active ingredient contained in Cymbalta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Doing so may cause unpleasant side effects, including nausea and headache. If you wish or need to stop taking Cymbalta, your doctor will tell you how to reduce your dose gradually over time. Combining Cymbalta and alcohol can cause serious side effects to occur. You should not use alcohol if you are taking this medication. If you must drink alcohol, it is recommended that you do so in moderation and only after you have been taking Cymbalta for a period of time. Drinking while you take Cymbalta could increase this risk. This is especially true if you drink heavily. Heavy drinking is usually defined as three or more alcoholic drinks per day. This is. In addition to knowing about the potential interaction of alcohol and side effects, some people have found that using Cymbalta has actually changed their drinking habits, so there is also information on the concepts of craving, blackout and side effects related to alcohol and Cymbalta.