Sexual side effects are common with antidepressants in both men and women, but there are options to prevent or reduce such side effects. Find a comprehensive guide to possible side effects including common and rare side effects when taking Pristiq (Desvenlafaxine Extended-Release Tablets) for healthcare professionals and consumers. Learn about the most frequently prescribed antidepressant medicines and their most common side effects. Pristiq is used to treat major depressive disorder in adults. Learn about side effects, interactions and indications. If you are still considering taking Pristiq, make yourself very aware of the possible side effects, and if you start to feel any side effects at all, talk to your doctor. Wellbutrin may affect the sex drive (also known as libido). In previous clinical studies documenting the side effects of Wellbutrin, a decreased sex drive occurred in up to 3.1 percent of people taking Wellbutrin. Learn about the potential side effects of Pristiq (desvenlafaxine). Includes common and rare side effects information for consumers and healthcare professionals. A: Changes in weight and appetite are common side effects of Wellbutrin (bupropion). Some patients find that switching to another antidepressant can help with weight gain. Common Wellbutrin Side Effects Wellbutrin has been studied thoroughly in clinical trials. In these studies, the side effects that occur in a group of people taking the drug are documented and are then compared to side effects that occur in another group of people not taking the medicine. Learn about Pristiq (Desvenlafaxine Extended-Release Tablets) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.