Applies to trazodone: compounding powder, oral tablet, oral tablet extended release General The most commonly reported side effects included drowsiness, dry mouth, dizziness, and lightheadedness. Common side effects of trazodone include nervousness, dizziness, drowsiness, confusion, blurred vision, nausea, dry mouth, diarrhea, constipation, and abnormal dreams. A search of a drug database. Trazodone (generic name: Desyrel ) increases the amount of a brain chemical called serotonin and is indicated for the treatment of major depressive disorder. Summary. Dry eye is found among people who take Trazodone hydrochloride, especially for people who are female, 60+ old also take medication Celebrex, and have Rheumatoid arthritis. I'm kind of weirded out. I've been taking Trazodone for 2 months now and I have the following side effects, from minor to scary:-dry eyes-growing tolerance, sleep inducing effects lessenings Trazodone is used to treat depression. Trazodone is in a class of medications called serotonin modulators. It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance. Can Trazodone cause Dry Eyes? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. - Page 2 Trazodone Trazodone HCl (generic Desyrel) is a modified cyclic antidepressant used as a treatment for depression. It may also be used for relief of an anxiety disorder (e.g., tension, sleeplessness), chronic pain or to treat other conditions as determined by your doctor. Dr. Khreim responded: Yes/No. Those are uncommon side effects of trazodone , however, medications can cause side effects either by themselves or interacting with other medications.I.E medication a added to b may raise. What other drugs will affect trazodone? Using trazodone with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.