The virus was first discovered in 1964 when Sir Michael Anthony Epstein and Ms. Yvonne Barr found it in a Burkitt lymphoma cell line. In 1968, the virus was linked to the disease infectious mononucleosis (glandular fever). Summary. Epstein-barr virus associated lymphoproliferative disorder is found among people who take Prednisone, especially for people who are male, 60+ old , have been taking the drug for 1 month, also take medication Mycophenolate Mofetil, and have Kidney transplant. Infectious mononucleosis (IM, mono), also known as glandular fever, is an infection usually caused by the Epstein–Barr virus (EBV). Most people are infected by the virus as children, when the disease produces few or no symptoms. In young adults, the disease often results in fever, sore throat, enlarged lymph nodes in the neck, and tiredness. Interestingly, extreme fatigue can also cause a reactivation of Epstein-Barr virus. Though there are many conditions where EBV is the cause or a trigger, extreme fatigue is a unifying symptom that occurs in most cases. Chronic Epstein-Barr virus often coincides with chronic illnesses like Lyme, fibromyalgia and multiple sclerosis. Learn the underlying link from Dr. Rawls. Epstein-Barr virus and autoimmune diseases At a Glance Researchers found a mechanism that may explain why the Epstein-Barr virus is associated with certain autoimmune illnesses such as lupus. Hi, I was just put on prednisone for my extreme mono I have had for 5 months- I''m taking 16mg 3 times per day for 3 days then 2 times per day for 3 days, then I'm taking 10mg two times per day for two days then one time per day for two days. Prednisone is a synthetic corticosteroid that reduces inflammation and suppresses the immune system. Prednisone is prescribed for a wide range of conditions, especially autoimmune diseases. Summary. Epstein-barr virus infection is found among people who take Prednisone, especially for people who are female, 60+ old , have been taking the drug for 1 - 6 months, also take medication Cyclosporine, and have Kidney transplant. Brandfonbrener A, Epstein A, Wu S, Phair J. Corticosteroid treatment of impending upper airway obstruction due to Epstein-Barr virus (EBV) infectious mononucleosis did not alter the pattern of lymphocyte changes induced by this viral infection during the first two weeks following administration of prednisone.