Yes you can take them together. What I do is stagger them, where I take tylenol for one dose then when it's time to take another I take ibuprofen. Taking them both together helps better for pain. What I do is stagger them, where I take tylenol for one dose then when it's time to take another I take ibuprofen. Hi beatmik, I do not think I would be mixing such large doses of the NSAIDS together, both Aleve OTC *over the counter* and Motrin are in that family, so your alternating with Motrin and Tylenol I would say is safe to use. These two can be taken together, and Tylenol does not recommend taking them together. You can indeed take both of these medications at the same time, and in fact your doctor may recommend that you do so. It these drugs are taken with Tylenol or Motrin, they can increase the risk of side effects. A Word From Verywell While acetaminophen and ibuprofen are relatively safe and effective when used together, there are considerations you need to make. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Khanna on can you mix motrin and advil: There should be no problem with this combination. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Khanna on can you mix motrin and advil: There should be no problem with this combination. He said I can give e her Tylenol and Motrin which I have been giving her but she keeps vomiting and won’t keep it down I keep putting her in the tub with lukewarm water and that seem to help for a little while then her temperature keeps going up Yes, you can safely take acetaminophen and ibuprofen together. This may surprise you, though: Taking these two medications together works better to relieve pain than taking them separately. Several large research studies have shown that ibuprofen (Advil, Motrin) and acetaminophen (Tylenol) together work well to relieve pain with few side effects. You can take both together, as they both perform different functions. There should be no side effects, given you have no side effects from either individually. Yes, you can take those together. Tylenol, (an analgesic), can be taken with any NSAID, but NSAIDs cannot be taken with other NSAIDs. Commonly available over-the-counter NSAIDs include ibuprofen, naproxen, and aspirin, under different brand names as well as store brand generics.