1. Nihon Yakurigaku Zasshi. 1986 May;87(5):557-71. [Effects of oxybutynin hydrochloride on the urinary bladder and urethra in in situ preparations]. Review key therapeutic options to manage urinary incontinence in dogs and cats. How to use Oxybutynin Chloride. Take this medication by mouth, usually 2-3 times a day, or as directed by your doctor. It may be taken with or without food. Oxybutynin suppresses involuntary contractions of the bladder's smooth muscle (spasms) by blocking the release of acetylcholine. This is referred to as an anticholinergic effect. Oxybutynin also directly relaxes the bladder's outer layer of muscle (the detrusor muscle). The FDA approved oxybutynin in July 1975. Oxybutynin, sold as under the brand names Ditropan among others, is a medication used to treat overactive bladder. It works similar to tolterodine. [1] While also used for bed wetting in children, evidence to support this use is poor. [1] Oxybutynin is used to control urgent, frequent, or uncontrolled urination in people who have overactive bladder (a condition in which the bladder muscles have uncontrollable spasms), spina bifida (a disability that occurs when the spinal cord does not close properly before birth), or other conditions that affect the bladder muscles. Oxybutynin Chloride Tablets prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side effects. Oxybutynin is an anticholinergic drug that is actually used in dogs to treat urinary incontinence. It doesn't work on the actual bladder sphinter, it works by relaxing the bladder muscle so that it is able to store more urine without feeling full. Find information about common, infrequent and rare side effects of Oxybutynin Chloride Oral. I don't want you to induce emesis in both of your cats. I would monitor them for the symptoms I mentioned and should one become symptomatic, have its vet treat symptomatically and supportively.