pharaoh got alot of Cyproheptadine (PERIACTIN) and want's to try it out some people say it cause euphoria does anybody tried it? how much to take for. If I have never taken Cyproheptadine before, how much would it take to get me high? Can Cyproheptadine cause Euphoria? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Best Answer: I was prescribed cyproheptadine for migraines too. I started out taking 4 to try and get high, but nothing really happened. How to use Cyproheptadine HCL. Take this medication by mouth with or without food as directed by your doctor, usually 2 to 3 times a day. If you are using the liquid form of this medication. Cyproheptadine HCl, USP is an antihistaminic and antiserotonergic agent. Cyproheptadine hydrochloride, USP is a white to slightly yellowish crystalline solid, with a molecular weight of 350.89, which is soluble in water, freely soluble in methanol, sparingly soluble in ethanol, soluble in chloroform, and practically insoluble in ether. Cyproheptadine, sold under the brand name Periactin among others, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties. It was patented in 1959 and came into medical use in 1961. Cyproheptadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Cyproheptadine is sometimes used to treat certain types of headaches, including migraines. Cyproheptadine may also Cyproheptadine for appetite can be highly effective in patients who have a reduced desire to eat, or need to gain weight. This medication is an antihistamine intended for the management of allergies, but can cause increased appetite as a side effect. Easy-to-read patient leaflet for Cyproheptadine Tablets. Includes indications, proper use, special instructions, precautions, and possible side effects.