What is restless leg syndrome (rls) Restless legs syndrome (RLS) also known as Willis-Ekbom disease, is a a neurological sensorimotor disease in which you have an uncontrollable urge to move your legs, usually due to leg discomfort 1). Das Restless-Legs-Syndrom (RLS, englisch für Syndrom der ruhelosen Beine) bezeichnet eine Art von Bewegungsstörung, die durch Missempfindungen und einen Bewegungsdrang in den Beinen und Füßen gekennzeichnet ist (weniger häufig auch in den Armen). Restless leg syndrome (a powerful urge to move your legs) has been reported by people with restless leg syndrome, depression, osteoporosis, multiple sclerosis, pain (latest reports from 31,750 Restless leg syndrome patients). Revisiting Restless Legs Syndrome and Leg Cramps in the Renal Patient Vivian Lee, B.Sc.Phm., R.Ph. Clinical Pharmacist, Peterborough Regional Renal Program Along with its needed effects, ondansetron (the active ingredient contained in Zofran) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Restless legs syndrome. Restless legs syndrome (RLS) is a common neurologic disorder that is largely under-diagnosed and under-treated. RLS is characterized by an urge to move the legs that is worse at rest and at bedtime. Nausea. Metoclopramide is commonly used to treat nausea and vomiting associated with conditions such as uremia, radiation sickness, cancer and the effects of chemotherapy, labor, infection, and emetogenic drugs. Restless legs syndrome treatment includes natural remedies that you can implement at home. Use exercise, sleep hygiene, and relaxation to treat RLS. Use exercise, sleep hygiene, and relaxation to treat RLS. Summary. Restless legs syndrome is found among people who take Ondansetron, especially for people who are female, 60+ old , have been taking the drug for 1 month, also take medication Zometa, and have Pain. Restless legs syndrome (RLS) is a common neurological disorder of unknown etiology that is managed by therapy directed at relieving its symptoms. Treatment of patients with milder symptoms that occur intermittently may be treated with nonpharmacological therapy but when not successful, drug therapy.