Reglan crosses the blood-brain barrier and can cause depression even in moms who feel fine. Symptoms of depression will go away once use is stopped. The longer Reglan is taken, the more likely the breastfeeding mother is to experience depression, so preferably it should not be taken for more than three weeks. I had to stop nursing for a week when my son was 2 weeks old b/c of a UTI (allergic to the medicine you can take while nursing). My pediatrician recommended Reglan to increase my milk. Reglan has often been used in the U.S. One major side-effect of Reglan is severe depression; it is contraindicated in moms with a history of depression, and all moms who take this should keep an eye out for signs of depression. In studies on Reglan (metoclopramide) and breastfeeding, the medication was shown to pass through breast milk, causing mild problems in the nursing infants. Reglan for breastfeeding moms? My doctor gave me reglan to increase my breastmilk supply. This was after we tried everything including working with herbs and La Leche. Hey everyone, Im new to breastfeeding and Im determined but my supply is low. Ive been working with a lactation consultant and she said if it didnt improve over the weekend by pumping and nursing at the least every 2 hours, that I should ask my GYN about Reglan. I took Reglan with my first baby because of lactation issues, and it did help a lot. My milk came in strong after 3 days, but once I stopped taking it, the milk dried up completely. My milk came in strong after 3 days, but once I stopped taking it, the milk dried up completely. In well-designed studies that evaluated the effectiveness of metoclopramide as a galactogogue in women who continue to have difficulty producing milk after nursing techniques have been optimized, it was of no additional benefit. Prophylactic use in the mothers of preterm infants has also shown little or no benefit. Reglan is an older prescription medication that is successful in increasing the milk production in some moms. However, I would caution you against trying it because about 10% of all mothers treated with it report nervousness, depression, fatigue, and irritability. Reglan Side-Effects? - Has anyone exprienced any side effects of Reglan, in yourselves or in your babies? - Breastfeeding Moms.