The most common antibiotics implicated in antibiotic-associated diarrhea are amoxicillin-clavulanate, ampicillin, and cefixime; however, other antibiotics may lead to this side effect, including cephalosporins, fluoroquinolones (e.g., side effects of Cipro antibiotic), azithromycin (e.g., Z Pak), clarithromycin (Biaxin), erythromycin, and tetracycline. 2 Probiotics such as Saccharomyces. Common Side Effects of Cipro Before you start taking Cipro, tell your doctor about any allergies, medical conditions, and medicines you take. Include over-the-counter medicines or herbal supplements, particularly antacids. Common side effects are headache, rash, and diarrhea. Possible serious side effects are central nervous system effects, hyperglycemia, and C. difficile associated diarrhea. Cipro is not safe to take if you pregnant or breastfeeding. Side effects are common with antibiotic, drugs such as Cipro. The most common side effects while taking Cipro include: The most common side effects while taking Cipro include: nausea Fluoroquinolones (Cipro, Levaquin, Avelox) are among the most commonly prescribed class of antibiotics in the United States, but they carry severe side effects that can harm your central nervous system, musculoskeletal, visual and renal systems, sometimes simultaneously. Cipro (ciprofloxacin) is a quinolone antibiotic. Cipro is available as a generic drug and is prescribed to treat infections of the skin, lungs, airways, bones, joints, and urinary tract infections caused by susceptible bacteria. Most people are able to take Cipro without any problems. However, some people do experience side effects during treatment. In clinical studies, the most common problems in adults included nausea, diarrhea, and abnormal liver function tests. Levaquin (levofloxacin) is an antibiotic for treating several types of bacterial infections. Levaquin is available in generic form. Common side effects of Levaquin include: The most common side effects (from clinical trials of all formulations, doses, durations of therapy, and indications) were nausea, diarrhea, abnormal liver function tests, vomiting, and rash. The most common side effects reported with the IV formulation were nausea, diarrhea, vomiting, injection and infusion site reactions, rash, and increased transaminases (transient). Find information about common, infrequent and rare side effects of Cipro Oral.