Can you please tell me if you can take Nexium 40mg. and Zantac 75mg. together or on the same day. My GI doctor has me on Nexium 40mg. and my PCP wants me to take Zantac 75mg. at night before I go to bed. Prilosec and Zantac come in tablet, capsule, and liquid forms that you take by mouth. For either drug, the typical length of treatment is two to eight weeks, depending on what you’re treating. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Ziring on can u take prilosec and zantac together: Usually it is one or the other. However you can use both if you have severe gerd or peptic ulcer disease, because of their different modes of action. If bleeding, sucralfate is added. You can take both gaviscon and omeprazole. However you should not take gaviscon at the same time as other tablets (I believe any other tablets) because they will reduce absorbancy and mean the the omeprazole (or any other tablet) is not absorbed at all or make it less effective. You should contact your doctor for clarification. Zantac (ranitidine) belongs to a group of drugs called histamine-2 blockers. Ranitidine works by reducing the amount of acid your stomach produces. It is important to take the Prilosec on an empty stomach 30 minutes before a meal. In addition, the Zantac needs to be given at a separate time than the Zantac. While both medications reduce acid. It would make no sense to take both Protonix and Prilosec. They are both PPI - Proton Pump Inhibitor Class medications. Both are close cousins of each other, the molecules are very similar and their method of action is identical. Can you please tell me if you can take Nexium 40mg. and Zantac 75mg. together or on the same day. My GI doctor has me on Nexium 40mg. and my PCP wants me to take Zantac 75mg. at night before I go to bed. Yes if necessary. Zantac is an H2 Blocker; Prilosec is a Proton Pump Inhibitor (PPI). They both inhibit acid production in the stomach, but Prilosec is more potent. Yes you can im on omeprazole (prilosec)20mg and ranitidine (zantac) 150mg doctors told me you can take them both but not at the same time same day but hours apart i take a prilosec when i wake up and a zantac before i go to sleep :).