Can Metoprolol cause Arthritis? Arthritis is a known side effect of Metoprolol. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Arthritis is a known side effect of Metoprolol. Find information about common, infrequent and rare side effects of Metoprolol Succinate Oral. Side Effects. See also Warning section. Drowsiness, dizziness, tiredness, diarrhea, and slow heartbeat may occur. Decreased sexual ability has been reported rarely. We studied people who take Metoprolol tartrate and have side effects from FDA. See what we found. Metoprolol is generally well tolerated. Side effects include. abdominal cramps, diarrhea, constipation, fatigue, insomnia, indigestion, nausea, depression, Metoprolol oral tablet can cause certain side effects. More common side effects. The more common side effects that can occur with metoprolol include: Summary. Arthritis is found among people who take Metoprolol tartrate, especially for people who are female, 60+ old , have been taking the drug for 1 - 6 months, also take medication Lisinopril, and have High blood cholesterol. There are a number of possible metoprolol side effects, it is best to speak to your doctor about these and consult with him/her should any of these persist and become bothersome. Metoprolol tartrate is a selective beta 1-adrenoreceptor blocking agent, available as 25 mg, 50 mg, and 100 mg tablets for oral administration. Along with its needed effects, metoprolol may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.