Isotretinoin was approved by the Food and Drug Administration (FDA) in 1982 and revolutionized acne therapy. Soon afterwards, case reports appeared suggesting a link between inflammatory bowel disease and use of isotretinoin. Here, we describe two cases of inflammatory bowel disease in two young female patients, after treatment with oral isotretinoin for severe acne vulgaris and hidradenitis suppurativa, respectively. Introduction. Isotretinoin is commonly prescribed for the treatment of severe acne. Though cases of inflammatory bowel disease (IBD) have been reported in isotretinoin users, a causal association remains unproven. Limited evidence suggests that isotretinoin may be associated with inflammatory bowel disease (IBD). To explore this association, we conducted a retrospective population-based cohort study in British Columbia, Canada, among participants who were newly treated with isotretinoin or topical acne medications. A purported association between isotretinoin and inflammatory bowel disease has generated continuing controversy. Background Isotretinoin was approved by the Food and Drug Administration (FDA) in 1982 and revolutionized acne therapy (Owens, 2014). OBJECTIVE:To report a case of inflammatory bowel disease (IBD) associated with use of isotretinoin.CASE SUMMARY:A 17-year-old boy presented with new-onset rectal bleeding after completion of a five-month course of isotretinoin. A diagnosis of ulcerative colitis was made. His condition worsened despite therapy with 5-aminosalicylic acid, steroid. Isotretinoin is commonly prescribed for the treatment of severe acne. Although cases of inflammatory bowel disease (IBD) have been reported in isotretinoin users, a causal association remains. Isotretinoin, also known as 13-cis-retinoic acid (and colloquially referred to by its former brand name Accutane or Roaccutane), is a medication primarily used to treat severe acne. Inflammatory Bowel Disease and Isotretinoin: Litigation Concerns Thu, - 20:34 Deciding whether or not to alert patients to any potential treatment warnings before performing a procedure or prescribing a medication is not always a cut-and-dried issue. Academia.edu is a platform for academics to share research papers.