Hydroxyzine and Zoloft. Using Zoloft together with hydroxyzine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. In some people, especially in the elderly, the combination of the two medicines may cause impairment in thinking, judgment, and motor coordination. It is, therefore, important to avoid activities requiring mental alertness such as. Applies to hydroxyzine: compounding powder, intramuscular solution, oral capsule, oral suspension, oral syrup, oral tablet. General. The most commonly reported side effects included sleepiness, headache, and tiredness. Nervous system. Very common (10% or more): Sleepiness (up to 13.74%) Common (1% to 10%): Headache. Rare (0.01% to 0.1%): Convulsion, tremor. Frequency not reported. Urinary incontinence. Clozapine is linked to urinary incontinence, though its appearance may be under-recognized. Withdrawal effects. Abrupt withdrawal may lead to cholinergic rebound effects, such as indigestion, diarrhea, nausea/vomiting, overabundance of saliva, profuse sweating, insomnia, and agitation. Urinary retention is the acute or chronic inability to voluntarily pass an adequate amount of urine. The condition predominantly affects men. The most common causes are obstructive in nature, with. WebMD provides common contraindications for hydroxyzine HCl oral. Find out what health conditions may be a health risk when taken with hydroxyzine HCl oral Hydroxyzine is given by mouth or injection and is used off label to treat allergic or itchy conditions. Give as directed. The most common side effect is sedation. Do not use in pets that are allergic to it or cetirizine, or pets that have heart failure, urinary obstruction, or stomach obstruction. If a negative reaction occurs, please call your veterinary office. Hydroxyzine may rarely cause acute generalized exanthematous pustulosis (AGEP), a serious skin reaction characterized by fever and numerous small, superficial, non-follicular, sterile pustules, arising within large areas of edematous erythema; if signs or symptoms suggest AGEP, do not resume use of hydroxyzine and consider alternative therapy; avoid cetirizine or levocetirizine in patients who. Hydroxyzine is contra-indicated in patients with prolonged QT-interval or who have risk factors for QT-interval prolongation;. (with high doses); urinary disorders; vertigo; vision disorders; vomiting. Side-effects, further information. Paradoxical stimulation may occur rarely, especially with high doses. Drowsiness may diminish after a few days of treatment. Allergy and cross-sensitivity. Hydroxyzine, sold under the brand names Atarax and others, is an antihistamine medication. It. or urinary tract. Use of hydroxyzine for premedication as a sedative has no effects on tropane alkaloids, such as atropine, but may, following general anesthesia, potentiate meperidine and barbiturates, and use in pre-anesthetic adjunctive therapy should be modified depending upon the state of the. Hydroxyzine is contraindicated during early pregnancy and there are reports that neonates exposed to hydroxyzine during late pregnancy or while being born have experienced central nervous system depression, clonic movements, extrapyramidal symptoms, low blood pressure, movement disorders, hypoxic conditions, or urinary retention. There are no controlled studies in humans and hydroxyzine should.