Promethazine VC with Codeine is a combination medicine used to treat runny or stuffy nose, sneezing, cough, and sinus congestion caused by allergies or the common cold. Codeine with promethazine is frequently prescribed to people to treat a wide variety of symptoms. Codeine with promethazine is a combination medicine that can treat the symptoms of the common cold, allergies, the flu, and various breathing illnesses like bronchitis and sinusitis. Another main component in these syrups, codeine is a type of narcotic analgesic – an opioid-based pain-reliever. It’s also a common compound found in prescription-strength cough suppressants as with promethazine/codeine syrup. Promethazine VC with codeine is part of the Antihistamine / Opioid Combinations class and treats Nasal Congestion, Allergic Rhinitis, Cold Symptoms, and other conditions. FDA Drug Safety Communication: FDA restricts use of prescription codeine pain and cough medicines and tramadol pain medicines in children; recommends against use in breastfeeding women Promethazine is used to relieve the symptoms of allergic reactions such as allergic rhinitis (runny nose and watery eyes caused by allergy to pollen, mold or dust), allergic conjunctivitis (red, watery eyes caused by allergies), allergic skin reactions, and allergic reactions to blood or plasma products. actually the first answer you recieved was rite and wrong! you cannot buy codeine/promethazine without a perscription that i know of. but you can buy codeine/guaifenesin cough syrup OTC (over the counter, without a perscription). it is known as cheratussin AC.it is widely available but depending on state law it may or may not be. for example i. Consumer information about the medication PROMETHAZINE/CODEINE SYRUP - ORAL (Phenergan w/ codeine), includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug PROMETHAZINE/CODEINE SYRUP - ORAL. Purple drank is a recreational drug which includes a prescription-strength cough syrup used in a manner inconsistent with its labeling and mixed with a carbonated soft drink. Compare prices and print coupons for Promethazine DM (Generic Pherazine DM) and other Nasal Congestion, Allergic Rhinitis, Cold Symptoms, and Cough drugs at CVS, Walgreens, and other pharmacies. Prices start at $5.83.