I have recently discovered I'm allergic to an antibiotic that was prescribed to me. The doctor then prescribed 40mg of Prednisone for one week, and 20mg the following week, along with Benadryl and Pepcid. I have the same thing going on with me. 21 days of hives, 2 rounds of 15 days of Prednisone piils and one shot. Waiting for my skin biopsy to come back from the Dermatologist. Waiting for my skin biopsy to come back from the Dermatologist. I have had hives for 4 days, since Thursday. I was prescribed prednisone on Saturday. I took 60 mg Saturday, 60mg Sunday & 60mg this morning. My hives have not subsided. Clean air just settle for medical help it is still be transferred to your complexion. This overgrowth that is reaching poses no danger to the village. Prednisone is a strong and great drug for certain problems, but it is no better than antihistamine treatment for patients who are itching with hives, said lead study author Dr. Caroline Barniol. how long will it take for prednisone to work on hives - ForSaleOnline. how long will it take for prednisone to work on hives - Get Pills. Brand and Generic products for sale. 100% secure bill. Hives keep coming back and I swear Prednisone doen’t work… As such, oral steroids like Prednisone may be used temporarily to relieve hives symptoms, but they should not be used for long-term treatment. How long does it take for the Prednisone to kick on and stop the hives from spreading. I'm on 40MG for 3 days now and it's still spreading now onto my face. How long does it take for the Prednisone to kick on and stop the hives from spreading. I also have Candida (yeast) still waiting for the biopsy to find what it is. 125 126 Reply Follow This Thread Stop Following This Thread Flag this Discussion i understand your frustration. I have been on prednisone for about 3months now. Have had mild case of chronic hives for 1.5years but last 3months have been hell.