Zoloft is commonly used to treat depression, panic disorder, social anxiety disorder, and other conditions. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs). Insomnia, weight gain, sexual dysfunction emerge as problems affecting compliance Physicians are seeing long-term side effects with selective serotonin reuptake inhibitors far in excess of what was expected from clinical trial data. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) antidepressant. Fluoxetine affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. Zoloft is a brand name of the active ingredient Sertraline that has been developed by the pharmaceutical company Pfizer. The serotonin inhibitor theory of why Prozac controls appetite is certainly logical, but there is one significant caveat. Researchers at Massachusetts General Hospital in Boston found that Paxil and Zoloft, which are brands of selective serotonin reuptake inhibitors, may actually cause weight gain. Zoloft is the brand name of sertraline, an antidepressant used to treat major depressive disorders. Zoloft is in a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). Prozac is the brand name of fluoxetine, a prescription drug used to treat depression. This antidepressant is in a class of drugs known as selective serotonin reuptake inhibitors, or SSRIs. Prozac (fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. Fluoxetine affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. Zoloft ® (sertraline hydrochloride) and other selective serotonin reuptake inhibitors (SSRIs for short) are known to cause withdrawal symptoms in those that quickly stop taking the medicine. Fluoxetine is an oral drug that is used primarily for treating depression. It is in a class of drugs called selective serotonin reuptake inhibitors (SSRIs), a class that includes citalopram , paroxetine and sertraline. Fluoxetine affects neurotransmitters, the chemicals that nerves within the brain use to communicate with each other.