The oxycodone In a straight 10 is different than Percocet. In Percocet, it is oxycodone hydrochloride, which not as potent as straight oxycodone. The small oxycodone 10s are definitely noticably stronger than Percocet 10s (generic). Dilaudid and other versions of hydromorphone are stronger drugs than oxycodone. These drugs are often used for serious pain caused by surgery, broken bones , or cancer. Oxycodone in itself is stronger than Hydrocodone. As for me personally, I would rather have the Percocet. However the hydrocodone in the 10 MG strength i As for me personally, I would rather have. oxycodone is the base pain killing ingredient in percocet, percocet = oxycodone and acetaminophen there for if same mg of oxycodone instant release. I am taking oxycodone for severe back pain but my son told me that some people are getting hurt because people want their prescription and i shouldnt tell anyone i am taking this med, but i thought all the problems are over oxycotin. he said mine is stronger. whats the difference and which is stronger? There are several opiates stronger than oxycodone. I am assume because of the high dose of Fentanyl you are on that your physician may choose to stay away from stronger opiates for break through. I am assume because of the high dose of Fentanyl you are on that your physician may choose to stay away from stronger opiates for break through. it is not that one is stronger than the other, it's just a conversion rate. To get a comparable dosage you take the oral morphine dose and divide by 3 and multiple bt 2. IE 30mg of morphine is equivalent to 20mg of oxycodone. However, a different. found that oxycodone, the drug in Percocet, was 1.5 times more potent than hydrocodone, the drug in Vicodin, when prescribed and taken at equal doses. Cost The pure oxycodone is a lot safer for your liver than the percocet, but if you want to boost the efficacy of your pills, you can take a tylenol or an advil with them from time to time if you're hurting more that day. Compare Oxycodone vs. Percocet, which is better for uses like: Pain, Chronic Pain and Breakthrough Pain. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Oxycodone 3.4/5 over Percocet 2.8/5 in overall satisfaction.