ATP ADP + Pi 2 Failure Rate and Reasons for Failure in Drug Development Smietana et al., Nature Reviews Drug Discovery 15, 379–380 (2016) Harrison, Nature Reviews Drug Discovery 15, 817–818 (2016) Atanas G Atanasov, IGAB PAS, Department of Molecular Biology, Faculty Member. Studies Molecular Medicine, Pharmacology, and Pharmacognosy. Professor and Head of Molecular Biology Department at IGAB PAS. Research interests in Molecular Medicine, Open Rosuvastatin, sold under the trade name Crestor among others, is a statin medication, used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. It is recommended to be used together with dietary changes, exercise, and weight loss. It is taken by mouth. CUBIC LIQUID CRYSTALLINE NANOPARTICLES (CUBOSOMES): A NOVEL CARRIER FOR DRUG DELIVERY. Lyotropic liquid crystalline systems, such as reversed bicontinuous cubic phases acquire progressive attention because of their unique microstructure and physicochemical properties. Rosuvastatina es un fármaco de origen totalmente sintético, miembro de la familia de las estatinas, usado para disminuir el colesterol y otros lípidos sanguíneos mediante la inhibición de la enzima HMG-CoA reductasa. The discovery of HMG-CoA (3-hydroxy-3-methylglutaryl-CoA) reductase inhibitors, called statins, was a breakthrough in the prevention of hypercholesterolemia and related diseases. Open R&D strategy, Diversification of global strategy, Supply chain revolution with RFID technology, Global new drug, New combination drug, Secure new drug pipeline, Pharmaceutical supply chain advancement. In the Discovery Study 911 adults in Sweden with high risk for cardiovascular disease were divided into two groups. One group took 10 mg of Crestor for 12 weeks and 83.4 percent of them reached the LDL goal of 100 mg per deciliter. By Dr. Neville Wilson. ( 30 July 2013 ) The recent widespread media reports, implicating dietary omega-3 as a risk factor for prostate cancer in males, is likely to generate public concerns about the purported health and safety benefits of dietary oily fish or fish oil supplements. El hallazgo de las estatinas es una de las manifestaciones que mejor define la moderna farmacología. Inicialmente se definió exactamente la diana terapéutica donde se deseaba actuar: la HMG-CoA reductasa, enzima involucrada en la síntesis del colesterol.