Compare Nitrofurantoin vs. Nitrofurantoin Macrocrystals, which is better for uses like: UTI, Bladder Inflammation and Bladder Infection. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. The active ingredient in Macrobid is nitrofurantoin monohydrate macrocrystals or nitrofurantoin mono/macro. Macrodantin , on the other hand, is typically taken 4 times daily. The active ingredient in Macrodantin is nitrofurantion macrocrystalline (sometimes just referred to as nitrofurantoin )—which differs a little from the type of nitrofurantoin in Macrobid. The Macrobid® brand of nitrofurantoin is a hard gelatin capsule shell containing the equivalent of 100 mg of nitrofurantoin in the form of 25 mg of nitrofurantoin macrocrystals and 75 mg of nitrofurantoin monohydrate. Each 100 mg nitrofurantoin capsules USP, (macrocrystals) contains lactose monohydrate NF, corn starch NF, talc USP, gelatin, iron oxide black, iron oxide yellow, titanium dioxide. The edible black ink contains: shellac, potassium hydroxide, propylene glycol and black iron oxide. macrocrystals (25% of the drug) and nitrofurantoin monohydrate (the remaining 75% of the drug). Nitrofurantoin macrocrystals have a slower Nitrofurantoin macrocrystals have a slower dissolution and rate of absorption than nitrofurantoin monohydrate. Based on urinary pharmacokinetic data, the extent and rate of urinary excretion of nitrofurantoin from the 100 mg Nitrofurantoin Capsules, USP (monohydrate/ macrocrystals) are similar to those of the 50 mg or 100 mg nitrofurantoin (macrocrystals). Approximately 20-25% of a single dose of nitrofurantoin is recovered from the urine unchanged over 24 hours. form of 25 mg of nitrofurantoin macrocrystals and 75 mg of nitrofurantoin monohydrate. The chemical name of nitrofurantoin macrocrystals is 1-[[[5-nitro-2-furanyl]methylene]amino]-2,4­ imidazolidinedione. Difference between Macrobid and nitrofurantoin Select $100 Fall Article Contest Winners!! Difference between Macrobid and nitrofurantoin. Medications Dec 4, 2007 (29,235 Views 8 Comments) by GLORIAmunchkin72 (Member). NITROFURANTOIN is an antibiotic. It is used to treat urinary tract infections. The lowest GoodRx price for the most common version of nitrofurantoin mono/macro is around $17.71, 67% off the average retail price of $54.99. How to use Nitrofurantoin MONO-MACRO. Take this medication by mouth with food as directed by your doctor, usually twice daily (every 12 hours). Swallow the medication whole for best results.