If the wrong dose is administered for any reason, do not wait to see if negative side effects occur. Contact a doctor immediately or stop by the emergency room. Desmopressin (DDAVP) for diabetes insipidus can be an effective treatment option. Speak with your doctor about this synthetic hormone to see if it may be right for you. 120 micrograms once daily, increased if necessary to 240 micrograms once daily, dose to be taken at bedtime, limit fluid intake from 1 hour before to 8 hours after administration, dose to be increased only if lower dose not effective, reassess after 3 months by withdrawing treatment for at least 1 week. Postoperative polyuria or polydipsia. By mouth. For Adult. Dose to be adjusted according to. Dose range is 0.1 to 1.2 mg divided into 2 or 3 doses. IV: 1 to 2 mcg twice a day Subcutaneously: 1 to 2 mcg twice a day Use in children requires careful fluid intake restrictions to prevent possible hyponatremia and water intoxication. The optimal dosage depends on the patient's response (duration of sleep and adequate, not excessive water turnover). Usual Pediatric Dose for Hemophilia A. Dose (Medscape monograph on desmopressin here) 0.3 micrograms/kg IV infused over 20-30 minutes. May be repeated q12hr for up to 6 doses, but complications may increase in likelihood over time (especially hyponatremia). In practice, DDAVP is usually given only as a one-time dose. Side effects DDAVP Injection 4 mcg/mL is administered as an intravenous infusion at a dose of 0.3 mcg DDAVP/kg body weight diluted in sterile physiological saline and infused slowly over 15 to 30 minutes. In adults and children weighing more than 10 kg, 50 mL of diluent is recommended; in children weighing 10 kg or less, 10 mL of diluent is recommended. Blood pressure and pulse should be monitored during. Desmopressin, sold under the trade name DDAVP among others, is a medication used to treat diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, and high blood urea levels. In hemophilia A and von Willebrand disease, it should only be used for mild to moderate cases. It may be given in the nose, by injection into a vein, by mouth, or under the tongue. In January, 2014, the FDA approved a new 40 mg/mL dose of this medication, injected three times per week, which is double the standard 20 mg/mL dose that is injected daily. The approval was based on benefits and safety demonstrated in a one-year phase III trial comparing the higher, less-frequent dose of the medication with placebo. The standard dosing option continues to be available. Desmopressin nasal (DDAVP. Your doctor may start you on a low dose of desmopressin nasal and adjust your dose depending on your condition. Follow these directions carefully. If you will be using the nasal spray, you should check the manufacturer's information to find out how many sprays your bottle contains. Keep track of the number of sprays you use, not including the priming sprays.