I have been on 60mg of Cymbalta for the past year due to Severe Depressive Dissorder and have recently felt like I was ready and in a much better state of mind to get off it as I feel I am ready and also sick of the side effects (It definently helped when I needed it). Cymbalta is the brand name for the drug duloxetine. It belongs to a class of drugs called serotonin-norepinephrine reuptake inhibitors (SNRIs). SNRIs work by changing the balance of the chemical. Cymbalta increases the action of serotonin and norepinephrine, which are natural neurotransmitters produced by the body. This effect of Cymbalta alleviates depression and anxiety and decrease pain signals in the brain, spinal cord, and nerves. Cymbalta works for a variety of conditions. I started taking Cymbalta in 2011 for depression as well as fibromyalgia and chronic pain. I started out at 30mg and gradually increased to 90mg. What Is Duloxetine And What Does It Treat? Duloxetine is an antidepressant medication that works in the brain. It is approved for the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), diabetic peripheral neuropathic pain (DPNP), fibromyalgia, and chronic musculoskeletal pain. Forum Stats Last Post Info; ARE YOU NEW HERE? Words from the wise about Cymbalta. The following items are based on the experiences of people posting on this board. Duloxetine (Cymbalta) is a drug used to treat fibromyalgia and nerve pain. Learn about side effects, drug interactions, dosages, warnings, and more. I went happily to my psychiatrist thinking my Cymbalta (60mg) might be pooping out. I certainly wasn't having any major issues with anxiety or depression ON Cymbalta (loved it- been on 5 1/2 yrs for a depression episode in 2008). Drugmaker Eli Lilly and Company has quietly settled hundreds of personal injury lawsuits involving patients who claim they experienced withdrawal symptoms while quitting Cymbalta. I am overwhelmed by the negative reviews on this site for Cymbalta. I just started yesterday. Does anyone have positive experiences on Cymbalta for depression and anxiety???.