If you are pregnant, you can take only regular-strength Tylenol. Take a regular dose of no more than 2 capsules at a time. 8 Dangerous OTC Meds These drugs have hidden dangers Learn about side. There is a major drug interaction between promethazine and methadone so it would be best to avoid taking them together. If you do have to take it together then your doctor should monitor you well. However, the codeine should be well past its peak, so if you wait a few more hours you could take the methadone with no worries about it interacting with the codeine. 01-08-2013, 07:20 3 yo0123yo Because Tylenol and Codeine contains AA strong painkillers which is dangerous to adults when taken too much and when taken during pregnancy, its affects the developing Embryo in a similar manner. Over-the-counter (OTC) medications are medications that you can buy from a pharmacist without a prescription. Patients often complain that OTC drugs should not be restricted during the Methadone Maintenance Treatment program because they are available without a prescription. All I can say is different strokes. just get ALL the info up front before you opt for methadone. Read More I have experienced w/d from methadone , morphine, oxycontin, codeine and hydrocodone. It depends how much you've taken of each drug and how high your tolerance is. if you've never taken either drug before and you take them both and your system isnt used to opiates you will get sick or worse. are you thinking taking the lortab while on methadone for addiction that both drugs mixed together will cancel each other out or cause. Methadone is an agonist like codeine so it may be supposed that the effects may be stronger with this combo than methadone only. You is sure that if you do the combo codeine+ buprenorphine you would suffer from withdrawal symptoms because bupe is an antagonist and codeine is an agonist. You can become addicted to codeine even if you're taking a combination product such as. Methadone helps prevent withdrawal symptoms and cravings. Let us call you. (888) 338-9135. Tapering off codeine can take anywhere from a few weeks to a few months. This method is. Opiate substitutes, such as methadone or suboxone, may be used in place of codeine to taper off use. These drugs. So if you take methadone and codeine at all close together, especially if you take the methadone before or at the same time as the codeine, you will get less of the desirable effects of the codeine but still get the side effects and dangers (sometimes even more of the side effects).