Missed Dose of Crestor Most people forget to take their pills from time to time. If this happens to you, take it as soon as you remember unless it is within 12 hours of your next dose. General Dosing Information. The dose range for CRESTOR in adults is 5 to 40 mg orally once daily. The usual starting dose is 10 to 20 mg once daily. The recommended starting dose for most people with high cholesterol is Crestor 10 mg once a day (although a starting dose of 20 mg daily can be used if you have very high cholesterol). When initiating Crestor therapy or switching from another HMG‑CoA reductase inhibitor therapy, the appropriate Crestor starting dose should first be utilized, and only then titrated according to the patient’s response and individualized goal of therapy. The starting dose for most adults is 5 mg once daily. The maximum dose is 40 mg daily, and this dose should be reserved for patients who do not adequately respond to a 20 mg dose. The maximum dose is 40 mg daily, and this dose should be reserved for patients who do not adequately respond to a 20 mg dose. CRESTOR dose range: 5 mg–40 mg once daily; the usual starting dose is 10 mg–20 mg once daily The 40 mg dose of CRESTOR should only be used for patients who do not reach a bad (LDL) cholesterol goal on the 20 mg dose Medscape - Hyperlipidemia, hypertriglyceridemia, hypercholesteremia-specific dosing for Ezallor, Crestor (rosuvastatin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Use 5 mg/day starting dose in people of Asian ancestry, who may build up higher drug levels and be at higher risk of myopathy. Rare reports of immune -mediated necrotizing myopathy (IMNM), characterized by increased serum creatine kinase that persists despite discontinuing statin. When initiating CRESTOR therapy or switching from another statin, the appropriate CRESTOR starting dose should first be used and only then titrated according to the patient's response and individualized goal of therapy 1.