Along with its needed effects, rosuvastatin (the active ingredient contained in Crestor) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Summary. Edema is found among people who take Crestor, especially for people who are female, 60+ old , have been taking the drug for 1 - 6 months, also take medication Lasix, and have Rheumatoid arthritis. Normal walking, running, jumping, etc caused no pain, weakness or instability and there was no swelling, bruising or other external indication of injury. Crestor side effects swelling. Common Questions and Answers about Crestor side effects swelling. crestor. I would only take statins now if there was no other choice and it was necessary. But research 'side effects' of both Crestor and Verapamil. I was on Verapamil for months, for erratic BP, and ended up with Pericarditis, possibly from the drug I was told, as I had no other triggers and it. Had swelling of feet and legs that went away after stopping Ctrestor because of muscle pain. weakness in the arms, hands, legs, or feet Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Detailed drug Information for Crestor. Includes common brand names, drug descriptions, warnings, side effects and dosing information. Includes common brand names, drug descriptions, warnings, side effects and dosing information. Can Crestor cause Swollen Ankles? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. There is no Foot, leg, and ankle swelling reported by people who take Crestor yet. This review analyzes which people have Foot, leg, and ankle swelling with Crestor. It is created by eHealthMe based on reports from FDA, and is updated regularly. Crestor (rosuvastatin) is used to lower cholesterol levels. Rosuvastatin is slightly less popular than other statins. It is available in brand and generic versions.