Elderly patients with dementia-related psychosis (having lost touch with reality due to confusion and memory loss) treated with this type of medicine are at an increased risk of death, compared to placebo (sugar pill). Seroquel and Seroquel XR (quetiapine) is an antipsychotic drug used to treat bipolar disorder and schizophrenia. Common side effects include agitation, headache, and upset stomach. Serious side effects include suicidal thoughts, prolonged erection, and stroke. Pregnancy and breastfeeding safety information is provided. While these symptoms can occur at low doses, they occur more frequently and with greater severity with high potency and at higher seroquel generic doses of first generation antipsychotic drugs. Seroquel is a psychotropic medication used to treat schizophrenia in adults and children who are at least 13 years old. Seroquel is also used in the treatment of major depression and bipolar disorder. SEROQUEL® Quetiapine fumarate. Consumer Medicine Information. What is in this leaflet. This leaflet answers some of the common questions people ask about SEROQUEL. Clinical trials with quetiapine did not indicate a difference in tolerability in the geriatric patient vs. younger adult patients. Elderly patients may be more sensitive to the sedative, anticholinergic, and orthostatic effects of quetiapine; consider a slower rate of dose titration and lower target dose in the older adult. MEDGUIDE SECTION Medication Guide SEROQUEL (SER-oh-kwell) (quetiapine fumarate) Tablets. Read this Medication Guide before you start taking SEROQUEL and each time you get a refill. Recommended Dosing. The recommended initial dose, titration, dose range and maximum SEROQUEL XR dose for each approved indication is displayed in Table 1 below. Dose Modifications in Elderly Patients. Consideration should be given to a slower rate of dose titration and a lower target dose in the elderly and in patients who are debilitated or who have a predisposition to hypotensive reactions [see Clinical Pharmacology (12.3)]. 4 of 41 mg/day to an effective dose, depending on the clinical response and tolerability of the individual patient. In elderly patients with MDD, initial dosing should begin at 50 mg on Days 1-3, the dose can be.