From what I understand the issue with most medicines is what they do with the INR at the time we start them. When I was started on warfarin I was already on an antidepressant and propranolol so that carried on. If you can't mix a drug with alcohol it has to have a warning on the bottle, I can't imagine cough medicine and alcohol would cause anything more than a stomach ache, but you should still take a. While you are taking warfarin, you should check with your doctor or pharmacist before taking any medicines, including cold medicines that you get over-the-counter at the drug store. Some of these cold medicines contain aspirin or other nonsteroidal anti-inflammatory drugs (Advil, Motrin, Aleve), which can interact with warfarin. Let me know if you have What cold medicines can I take while taking coumadin 3 posts · Coumadin - Drug Interactions (Coumadin®) Drug Interactions - Tylenol is the best pain relieving medicine to take while on warfarin when Many cough and cold products contain I feel a cold coming on. Can I take Cough Syrup with Coumadin? There is a moderate interaction between Cough Syrup and Coumadin. You may want to consider another combination. This might actually seem like a strange answer. I just thought I'd warn you before answering. Anytime I feel a sore throat or cough coming on, I take. What cold medicine can I take with warfarin? - Answered by a verified Doctor. We use cookies to give you the best possible experience on our website. By continuing to use this site you consent to the use of cookies on your device as described in our cookie policy unless you have disabled them. Medical. Have medical questions? Ask a doctor online! Connect one-on-one with 0 who will answer. If you are taking coumadin, (warfarin) your underlying condition may make you more susceptible to infections, so check with your doctor if you need anything more than a cold med. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Werner on are there cold medicines that are ok to take when you are on coumadin.But they are also pretty useless most of the time.