Most people can safely take melatonin or valerian root to help improve their sleep patterns. As with other prescription sleep aids and other supplements, taking more than one at a time could pose potential health risks. Can I take Valerian Root Extract with Wellbutrin? There is no known interaction between Valerian Root Extract and Wellbutrin in our records. However, an interaction may still exist. It is best to avoid taking valerian with Lexapro. There is a moderate interaction between these medicines. Please see link below for more detailed information. Valerian root is a natural way to combat anxiety, stress and nervousness. Generally, people who take this herb report mild beneficial effects. ** Can You Take A Sleep Aid With Lexapro Why Do People Suffer From Insomnia ** Nature Sound Mp3 Can T Go Sleep Can You Take A Sleep Aid With Lexapro Why Do People Suffer From Insomnia with Is Honey Healthy To Eat and How To Get Nice Sleep At Night Bedtime Snack To Help You Sleep. Taking Paxil with herbal supplements may result in harmful interactions, including serotonin syndrome, a condition that can cause confusion, hallucinations, coma and death. Consult your doctor before taking dietary supplements with Paxil. I believe it is ok to take the Valerian Root with Lexapro. I'm just not positive. Hopefully someone else that is certain will respond. Things should start getting a little better everyday now. Valerian seems to be most effective after you take it regularly for two or more weeks. Because dosages varied in studies involving valerian and some studies weren't rigorous, it's not clear what dose is most effective or for how long you should take a particular dose. Consult your doctor before you take valerian along with Lexapro. Alcohol can increase drowsiness when taken with valerian and can increase side effects of Lexapro. John’s wort, SAMe, kava, ginseng, L-tryptophan, goldenseal, melatonin and yerba mansa. Drug interactions are reported among people who take Lexapro and Valerian together. This study is created by eHealthMe based on reports of 6 people who take Lexapro and Valerian from FDA, and is updated regularly.