Medicine question. I wouldn't take the two together as they both contain naproxen. You would be getting too much. Take just the sudafed pressure+pain if you have sinus issues. It's usually permissible to take both ibuprofen and Sudafed, a brand name for pseudoephedrine, says Drugs.com. People who have taken an MAO inhibitor in the past two weeks should not take these two drugs. Yes you can. In fact, pseudoephedrine HCL (the active incgredient in Sudafed) is combined with ibuprofen in many cold and sinus pills, such as AdvilAdvil® Cold & Sinus [OTC]; Dristan® Sinus [OTC. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID). Pseudoephedrine is a decongestant. Naproxen and pseudoephedrine is a combination medicine used to treat stuffy nose, sinus congestion, headache, fever, and minor aches and pains caused by the common cold or flu. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Rivas on aleve and sudafed: There is no significant overlap in these meds if taken at reasonable doses. can sudafed and naproxyn sodium be taken at the same time. Yes, as long as it is just plain Sudafed and not already in combination with ibuprofen-some of the cold formulas contain more than one medication often in combination with a pain reliever and some use ibuprofen as the pain reliever. They’re not contraindicated together, but that doesn’t mean you should take them together, especially if you have another condition, such as asthma. Summary. Drug interactions are reported among people who take Sudafed and Aleve together. This study is created by eHealthMe based on reports of 183 people who take Sudafed and Aleve from FDA, and is updated regularly. Naproxen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).