Advil Cold & Sinus caplets shrink swollen nasal passages to open up your airways. This non-drowsy formula also has the pain-relieving power of Advil to relieve your sinus pain. Important Information. Ibuprofen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. If you are looking for an additional analgesic to use with Advil Cold and Sinus, you should consider Tylenol (acetaminophen), which is safe to take and does not interact. Section Summary Advil Cold and Sinus contains ibuprofen as an active ingredient. Advil Allergy Sinus contains a combination of chlorpheniramine, ibuprofen, and pseudoephedrine. Advil Allergy Sinus is used to treat sneezing, itching, watery eyes, runny nose, stuffy nose, sinus congestion, cough, and pain or fever and other symptoms caused by the common cold or flu. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Miller on how many advil cold and sinus can i take: The Advil IS ibuprofen. It's rare, but it can lead to bleeding w/ lexapro (escitalopram) in some folk. Watch for signs and call Dr immediately. It can also cause dizziness and fainting, so be careful and try to have. Sinus congestion can also be associated with the swelling of the tissues in the nose known as inflammation. The result is a shrinking of your airways. The result is a shrinking of your airways. Advil ® Cold & Sinus combines the relief of a strong decongestant to open your airways with the power of Advil ® to relieve the pain commonly associated with sinus pressure. Ibuprofen can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine. Advil ® Sinus Congestion & Pain combines the speed and strength of Advil ® and a proven nasal decongestant for fast, effective relief of sinus pressure and congestion associated with colds. Can I take Advil® for a cold or the flu? Advil® Tablets, Gel Caplets, Liqui-Gels® and Liqui-Gels® minis contain an active ingredient, called ibuprofen, which temporarily reduces fever, as well as relieves minor aches and pains due to the common cold. If you have additional symptoms, you can also consider using Advil® Cold & Sinus and Advil® Sinus Congestion & Pain products for additional relief. These products contain ibuprofen plus a nasal decongestant to provide relief for symptoms including: headache, fever, minor body aches and pains, sinus pressure, and nasal congestion.