Aromatase inhibition is the gold standard for treatment of early and advanced breast cancer in postmenopausal women suffering from an estrogen receptor-positive disease. Compare Arimidex vs. Letrozole, which is better for uses like: Breast Cancer and Water Retention. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Arimidex and Letrozole evenly with 2.9/5. Arimidex did make a bad situation worse. Nighty Night tea by Traditional is wonderful to help calm you down at bed time. I but it from Amazon- boxes at a time. It has passion flower in it. Nighty Night tea by Traditional is wonderful to help calm you down at bed time. Compare Anastrozole vs Letrozole head-to-head for uses, ratings, cost, side effects, interactions and more. Anastrozole rated 5.7/10 vs Letrozole rated 6.2/10 in overall patient satisfaction. I has some very extreme difficult side effects on arimidex and then Femara. I am currently on tamoxifen until I can have carpal tunnel surgery from the arimidex. I am currently on tamoxifen until I can have carpal tunnel surgery from the arimidex. also, the cost of Arimidex, and which my oncologist prescribed first, is almost $400 for a months supply, of which my insurance covered 85%, but not all do. The Femara was something like $90 and my copayment was the same for that, $40. Compare Arimidex vs. Femara, which is better for uses like: Breast Cancer and Water Retention. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Femara 3.3/5 over Arimidex 2.9/5 in overall satisfaction. Compare Anastrozole vs Femara head-to-head for uses, ratings, cost, side effects, interactions and more. Anastrozole rated 5.7/10 vs Femara rated 6.9/10 in overall patient satisfaction. Anastrozole rated 5.7/10 vs Femara rated 6.9/10 in overall patient satisfaction. Hi Betsy, I started Femara, switched to Arimidex and then tried Aromisin. Sorry to say they all attacked by bones and muscles until I could barely walk without pain.