I have been taking 80mg twicw a day for degenerative arthritis and fibromyalgia but this has stopped being effective, On a recent visit with my physician he prescribed 100 mg Nucynta every 6 hrs to be taken along with my oxycontin. Compare Hydrocodone vs. Nucynta, which is better for uses like: Pain, Chronic Pain and Severe Pain. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Nucynta 3.8/5 over Hydrocodone 3.1/5 in overall satisfaction. Is Nucynta Better Than Other Pain Meds? Dr. Sharon Orrange Dr. Orrange is an Associate Professor of Clinical Medicine in the Division of Geriatric, Hospitalist and General Internal Medicine at the Keck School of Medicine of USC. I'm still scared to pieces to take Nucynta, I'm going to ask if I can break it in half wait an hour, if ok take the other half. It's how I finally started the hydro. It's how I finally started the hydro. hydrocodone-acetaminophen oral , tapentadol oral. Either increases toxicity of the other by pharmacodynamic synergism. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options anosevad: Navigation: Page d'accueil: Contact: signatur iphone funny: natasha curry 2011: can i take geodon and flexeril together I was clearly told to take Nucynta in lieu of Hydrocodone. This was prescribed by a PA and not a doctor. I will say that the PA seemed very thoughtful and very knowledgeable and he presented this as let's give it a try. I am allergic to codiene so can't take many meds. Nucynta has helped me so much. It takes the numbness and tingling away and keeps the shocks under control. I thank God for this every day. Makes. You can take Nucynta (tapentadol) with or without food; it makes no difference. Norco (hydrocodone / acetaminophen) has two medicines to treat moderate to moderately severe pain. The combination is more effective than either drug alone. Never take Nucynta in larger amounts, or for longer than prescribed. Do not crush, break, or open an extended-release tablet. Swallow it whole to avoid exposure to a potentially fatal dose. Do not crush, break, or open an extended-release tablet.