Amiodarone is the most effective antiarrhythmic drug available. In most countries (including Australia), amiodarone is the most commonly prescribed antiarrhythmic apart from drugs such as digoxin and beta blockers. Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of irregular heartbeats. This includes ventricular tachycardia (VT), ventricular fibrillation (VF), and wide complex tachycardia, as well as atrial fibrillation and paroxysmal supraventricular tachycardia. Evidence in cardiac arrest, however, is poor. It can. Amiodarone is predicted to increase the exposure to afatinib. Manufacturer advises separate administration by 12 hours. What other drugs will affect amiodarone? Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective. Read about amiodarone (Cordarone, Nextrone, Pacerone), a drug used for many serious arrhythmias of the heart including ventricular fibrillation, ventricular tachycardia, atrial fibrillation, and atrial flutter. Side effects, drug interactions, dosing and storage information, and pregnancy information is included. Amiodarone is used to treat certain types of serious irregular heartbeat. Learn about side effects, drug interactions, dosages, warnings, and more. Introduction Amiodarone is a potent arrhythmia suppressing agent that has been clearly linked to several distinct forms of drug induced liver disease. Amiodarone may be taken with or without food but should be taken at the same way each time. You should avoid consuming grapefruits and grapefruit juice while taking amiodarone. Click here for Frequently Asked Questions on Amiodarone. Amiodarone is a medication commonly used to treat patients with irregular heart beats, or cardiac arrhythmias. AMIODARONE is an antiarrhythmic drug. It helps make your heart beat regularly. Because of the side effects caused by this medicine, it is only used when other medicines have not worked.